3WBL

Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor

Summary for 3WBL

Entry DOI	10.2210/pdb3wbl/pdb
Related	3A2C
Descriptor	Cyclin-dependent kinase 2, ACETATE ION, N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine, ... (4 entities in total)
Functional Keywords	binding sites, tumor, cyclin-dependent kinase 2, drug design, map kinase kinase 2, mk2, protein kinase inhibitors, pyrazoles, pyrimidines, structure-activity relationship, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34401.99
Authors	Fujino, A.,Fukushima, K.,Kubota, T.,Kosugi, T.,Takimoto-Kamimura, M. (deposition date: 2013-05-20, release date: 2013-10-30, Last modification date: 2023-11-08)
Primary citation	Fujino, A.,Fukushima, K.,Kubota, T.,Kosugi, T.,Takimoto-Kamimura, M. Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity. J.SYNCHROTRON RADIAT., 20:905-909, 2013 Cited by PubMed: 24121337 DOI: 10.1107/S0909049513020736 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation