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3A2C

Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2)

Summary for 3A2C
Entry DOI10.2210/pdb3a2c/pdb
DescriptorMAP kinase-activated protein kinase 2, N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine, SULFATE ION (3 entities in total)
Functional Keywordsgly-rich loop formed, aipha-helix, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains12
Total formula weight459147.09
Authors
Fujino, A.,Takimoto-Kamimura, M. (deposition date: 2009-05-12, release date: 2010-05-12, Last modification date: 2023-11-01)
Primary citationFujino, A.,Fukushima, K.,Namiki, N.,Kosugi, T.,Takimoto-Kamimura, M.
Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800
Acta Crystallogr.,Sect.D, 66:80-87, 2010
Cited by
PubMed: 20057052
DOI: 10.1107/S0907444909046411
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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