3A2C
Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | MAP kinase-activated protein kinase 2 | polymer | 324 | 37521.3 | 12 | UniProt (P49137) Pfam (PF00069) | Homo sapiens (human) | MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2 |
| 2 | AA, BA, CA, DA, EA... (G, H, I, J, K...) | N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine | non-polymer | 366.5 | 24 | Chemie (PDY) | |||
| 3 | Y (F) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 450256.0 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 8891.1 | |
| All* | Total formula weight | 459147.1 |
