3W6G

Structure of peroxiredoxin from anaerobic hyperthermophilic archaeon Pyrococcus horikoshii

Summary for 3W6G

Entry DOI	10.2210/pdb3w6g/pdb
Descriptor	Probable peroxiredoxin, CITRATE ANION (3 entities in total)
Functional Keywords	reduction, hydrogen peroxide, water, oxidoreductase
Biological source	Pyrococcus horikoshii
Total number of polymer chains	20
Total formula weight	499595.90
Authors	Nakamura, T.,Mori, A.,Niiyama, M.,Matsumura, H.,Tokuyama, C.,Morita, J.,Uegaki, K.,Inoue, T. (deposition date: 2013-02-14, release date: 2013-07-10, Last modification date: 2024-03-20)
Primary citation	Nakamura, T.,Mori, A.,Niiyama, M.,Matsumura, H.,Tokuyama, C.,Morita, J.,Uegaki, K.,Inoue, T. Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii Acta Crystallogr.,Sect.F, 69:719-722, 2013 Cited by PubMed Abstract: The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 Å. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx). PubMed: 23832195 DOI: 10.1107/S1744309113014036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation