Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3W6G

Structure of peroxiredoxin from anaerobic hyperthermophilic archaeon Pyrococcus horikoshii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0033554	biological_process	cellular response to stress
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0055114	biological_process	obsolete oxidation-reduction process
A	0071453	biological_process	cellular response to oxygen levels
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0033554	biological_process	cellular response to stress
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0055114	biological_process	obsolete oxidation-reduction process
B	0071453	biological_process	cellular response to oxygen levels
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0033554	biological_process	cellular response to stress
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0055114	biological_process	obsolete oxidation-reduction process
C	0071453	biological_process	cellular response to oxygen levels
C	0098869	biological_process	cellular oxidant detoxification
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0033554	biological_process	cellular response to stress
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0055114	biological_process	obsolete oxidation-reduction process
D	0071453	biological_process	cellular response to oxygen levels
D	0098869	biological_process	cellular oxidant detoxification
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0033554	biological_process	cellular response to stress
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0055114	biological_process	obsolete oxidation-reduction process
E	0071453	biological_process	cellular response to oxygen levels
E	0098869	biological_process	cellular oxidant detoxification
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0033554	biological_process	cellular response to stress
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0055114	biological_process	obsolete oxidation-reduction process
F	0071453	biological_process	cellular response to oxygen levels
F	0098869	biological_process	cellular oxidant detoxification
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0004601	molecular_function	peroxidase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0033554	biological_process	cellular response to stress
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0055114	biological_process	obsolete oxidation-reduction process
G	0071453	biological_process	cellular response to oxygen levels
G	0098869	biological_process	cellular oxidant detoxification
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	0004601	molecular_function	peroxidase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0033554	biological_process	cellular response to stress
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0055114	biological_process	obsolete oxidation-reduction process
H	0071453	biological_process	cellular response to oxygen levels
H	0098869	biological_process	cellular oxidant detoxification
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	0004601	molecular_function	peroxidase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0033554	biological_process	cellular response to stress
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0055114	biological_process	obsolete oxidation-reduction process
I	0071453	biological_process	cellular response to oxygen levels
I	0098869	biological_process	cellular oxidant detoxification
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	0004601	molecular_function	peroxidase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0033554	biological_process	cellular response to stress
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0055114	biological_process	obsolete oxidation-reduction process
J	0071453	biological_process	cellular response to oxygen levels
J	0098869	biological_process	cellular oxidant detoxification
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
K	0004601	molecular_function	peroxidase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006979	biological_process	response to oxidative stress
K	0008379	molecular_function	thioredoxin peroxidase activity
K	0016209	molecular_function	antioxidant activity
K	0016491	molecular_function	oxidoreductase activity
K	0033554	biological_process	cellular response to stress
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0045454	biological_process	cell redox homeostasis
K	0051920	molecular_function	peroxiredoxin activity
K	0055114	biological_process	obsolete oxidation-reduction process
K	0071453	biological_process	cellular response to oxygen levels
K	0098869	biological_process	cellular oxidant detoxification
K	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
L	0004601	molecular_function	peroxidase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006979	biological_process	response to oxidative stress
L	0008379	molecular_function	thioredoxin peroxidase activity
L	0016209	molecular_function	antioxidant activity
L	0016491	molecular_function	oxidoreductase activity
L	0033554	biological_process	cellular response to stress
L	0042744	biological_process	hydrogen peroxide catabolic process
L	0045454	biological_process	cell redox homeostasis
L	0051920	molecular_function	peroxiredoxin activity
L	0055114	biological_process	obsolete oxidation-reduction process
L	0071453	biological_process	cellular response to oxygen levels
L	0098869	biological_process	cellular oxidant detoxification
L	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
M	0004601	molecular_function	peroxidase activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006979	biological_process	response to oxidative stress
M	0008379	molecular_function	thioredoxin peroxidase activity
M	0016209	molecular_function	antioxidant activity
M	0016491	molecular_function	oxidoreductase activity
M	0033554	biological_process	cellular response to stress
M	0042744	biological_process	hydrogen peroxide catabolic process
M	0045454	biological_process	cell redox homeostasis
M	0051920	molecular_function	peroxiredoxin activity
M	0055114	biological_process	obsolete oxidation-reduction process
M	0071453	biological_process	cellular response to oxygen levels
M	0098869	biological_process	cellular oxidant detoxification
M	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
N	0004601	molecular_function	peroxidase activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006979	biological_process	response to oxidative stress
N	0008379	molecular_function	thioredoxin peroxidase activity
N	0016209	molecular_function	antioxidant activity
N	0016491	molecular_function	oxidoreductase activity
N	0033554	biological_process	cellular response to stress
N	0042744	biological_process	hydrogen peroxide catabolic process
N	0045454	biological_process	cell redox homeostasis
N	0051920	molecular_function	peroxiredoxin activity
N	0055114	biological_process	obsolete oxidation-reduction process
N	0071453	biological_process	cellular response to oxygen levels
N	0098869	biological_process	cellular oxidant detoxification
N	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
O	0004601	molecular_function	peroxidase activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006979	biological_process	response to oxidative stress
O	0008379	molecular_function	thioredoxin peroxidase activity
O	0016209	molecular_function	antioxidant activity
O	0016491	molecular_function	oxidoreductase activity
O	0033554	biological_process	cellular response to stress
O	0042744	biological_process	hydrogen peroxide catabolic process
O	0045454	biological_process	cell redox homeostasis
O	0051920	molecular_function	peroxiredoxin activity
O	0055114	biological_process	obsolete oxidation-reduction process
O	0071453	biological_process	cellular response to oxygen levels
O	0098869	biological_process	cellular oxidant detoxification
O	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
P	0004601	molecular_function	peroxidase activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006979	biological_process	response to oxidative stress
P	0008379	molecular_function	thioredoxin peroxidase activity
P	0016209	molecular_function	antioxidant activity
P	0016491	molecular_function	oxidoreductase activity
P	0033554	biological_process	cellular response to stress
P	0042744	biological_process	hydrogen peroxide catabolic process
P	0045454	biological_process	cell redox homeostasis
P	0051920	molecular_function	peroxiredoxin activity
P	0055114	biological_process	obsolete oxidation-reduction process
P	0071453	biological_process	cellular response to oxygen levels
P	0098869	biological_process	cellular oxidant detoxification
P	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
Q	0004601	molecular_function	peroxidase activity
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006979	biological_process	response to oxidative stress
Q	0008379	molecular_function	thioredoxin peroxidase activity
Q	0016209	molecular_function	antioxidant activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0033554	biological_process	cellular response to stress
Q	0042744	biological_process	hydrogen peroxide catabolic process
Q	0045454	biological_process	cell redox homeostasis
Q	0051920	molecular_function	peroxiredoxin activity
Q	0055114	biological_process	obsolete oxidation-reduction process
Q	0071453	biological_process	cellular response to oxygen levels
Q	0098869	biological_process	cellular oxidant detoxification
Q	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
R	0004601	molecular_function	peroxidase activity
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006979	biological_process	response to oxidative stress
R	0008379	molecular_function	thioredoxin peroxidase activity
R	0016209	molecular_function	antioxidant activity
R	0016491	molecular_function	oxidoreductase activity
R	0033554	biological_process	cellular response to stress
R	0042744	biological_process	hydrogen peroxide catabolic process
R	0045454	biological_process	cell redox homeostasis
R	0051920	molecular_function	peroxiredoxin activity
R	0055114	biological_process	obsolete oxidation-reduction process
R	0071453	biological_process	cellular response to oxygen levels
R	0098869	biological_process	cellular oxidant detoxification
R	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
S	0004601	molecular_function	peroxidase activity
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006979	biological_process	response to oxidative stress
S	0008379	molecular_function	thioredoxin peroxidase activity
S	0016209	molecular_function	antioxidant activity
S	0016491	molecular_function	oxidoreductase activity
S	0033554	biological_process	cellular response to stress
S	0042744	biological_process	hydrogen peroxide catabolic process
S	0045454	biological_process	cell redox homeostasis
S	0051920	molecular_function	peroxiredoxin activity
S	0055114	biological_process	obsolete oxidation-reduction process
S	0071453	biological_process	cellular response to oxygen levels
S	0098869	biological_process	cellular oxidant detoxification
S	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
T	0004601	molecular_function	peroxidase activity
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006979	biological_process	response to oxidative stress
T	0008379	molecular_function	thioredoxin peroxidase activity
T	0016209	molecular_function	antioxidant activity
T	0016491	molecular_function	oxidoreductase activity
T	0033554	biological_process	cellular response to stress
T	0042744	biological_process	hydrogen peroxide catabolic process
T	0045454	biological_process	cell redox homeostasis
T	0051920	molecular_function	peroxiredoxin activity
T	0055114	biological_process	obsolete oxidation-reduction process
T	0071453	biological_process	cellular response to oxygen levels
T	0098869	biological_process	cellular oxidant detoxification
T	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC A 301

Chain	Residue
A	PRO39
A	THR43
A	PRO44
A	VAL45
A	CYS46
A	ARG121
A	ALA140
B	ALA165
B	PRO184

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC B 301

Chain	Residue
A	ALA165
A	PRO183
A	PRO184
B	PRO39
B	THR43
B	PRO44
B	VAL45
B	CYS46
B	ARG121
B	ALA140

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC C 301

Chain	Residue
C	PRO39
C	THR43
C	PRO44
C	VAL45
C	CYS46
C	ARG121
C	ALA140
C	HOH431
D	ALA165
D	PRO183
D	PRO184

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC D 301

Chain	Residue
C	ALA165
C	PRO183
C	PRO184
D	PRO39
D	THR43
D	PRO44
D	VAL45
D	CYS46
D	ARG121
D	ALA140

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC E 301

Chain	Residue
E	PRO39
E	THR43
E	PRO44
E	VAL45
E	CYS46
E	ARG121
E	ALA140
E	HOH435
F	ALA165
F	PRO184

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC F 301

Chain	Residue
E	ALA165
E	PRO184
F	PRO39
F	THR43
F	PRO44
F	VAL45
F	CYS46
F	ARG121
F	ALA140
F	HOH421

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC G 301

Chain	Residue
G	PRO39
G	THR43
G	PRO44
G	VAL45
G	CYS46
G	ARG121
G	ALA140
H	ALA165
H	PRO183
H	PRO184

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC H 301

Chain	Residue
G	ALA165
G	PRO183
G	PRO184
H	PRO39
H	THR43
H	PRO44
H	VAL45
H	CYS46
H	ARG121
H	ALA140

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC I 301

Chain	Residue
I	PRO39
I	THR43
I	PRO44
I	VAL45
I	CYS46
I	ARG121
I	ALA140
J	ALA165
J	PRO184

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC J 301

Chain	Residue
I	ALA165
I	PRO183
I	PRO184
J	PRO39
J	THR43
J	PRO44
J	VAL45
J	CYS46
J	ARG121
J	ALA140

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC K 301

Chain	Residue
K	PRO39
K	THR43
K	PRO44
K	VAL45
K	CYS46
K	ARG121
K	ALA140
L	ALA165
L	PRO183
L	PRO184

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC L 301

Chain	Residue
K	ALA165
K	PRO183
K	PRO184
L	PRO39
L	THR43
L	PRO44
L	VAL45
L	CYS46
L	ARG121
L	ALA140

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC M 301

Chain	Residue
M	PRO39
M	THR43
M	PRO44
M	VAL45
M	CYS46
M	ARG121
M	ALA140
N	ALA165
N	PRO183
N	PRO184

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC N 301

Chain	Residue
M	ALA165
M	PRO183
M	PRO184
N	PRO39
N	THR43
N	PRO44
N	VAL45
N	CYS46
N	ARG121
N	ALA140

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC O 301

Chain	Residue
O	PRO39
O	THR43
O	PRO44
O	VAL45
O	CYS46
O	ARG121
O	ALA140
P	ALA165
P	PRO183
P	PRO184

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC P 301

Chain	Residue
O	ALA165
O	PRO184
P	PRO39
P	THR43
P	PRO44
P	VAL45
P	CYS46
P	ILE118
P	ARG121
P	ALA140

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC Q 301

Chain	Residue
Q	PRO39
Q	THR43
Q	PRO44
Q	VAL45
Q	CYS46
Q	ARG121
Q	ALA140
R	PRO183
R	PRO184

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC R 301

Chain	Residue
Q	ALA165
Q	PRO183
Q	PRO184
R	THR43
R	PRO44
R	VAL45
R	CYS46
R	ARG121
R	ALA140
R	HOH432

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC S 301

Chain	Residue
S	THR43
S	PRO44
S	VAL45
S	CYS46
S	ARG121
S	ALA140
S	HOH444
T	ALA165
T	PRO183
T	PRO184

site_id	CC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC T 301

Chain	Residue
S	ALA165
S	PRO183
S	PRO184
T	PRO39
T	THR43
T	PRO44
T	VAL45
T	CYS46
T	ARG121
T	ALA140

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000255\|HAMAP-Rule:MF_00401, ECO:0000269\|PubMed:23832195

Chain	Residue	Details
A	CYS46
J	CYS46
K	CYS46
L	CYS46
M	CYS46
N	CYS46
O	CYS46
P	CYS46
Q	CYS46
R	CYS46
S	CYS46
B	CYS46
T	CYS46
C	CYS46
D	CYS46
E	CYS46
F	CYS46
G	CYS46
H	CYS46
I	CYS46

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00401

Chain	Residue	Details
A	ARG121
J	ARG121
K	ARG121
L	ARG121
M	ARG121
N	ARG121
O	ARG121
P	ARG121
Q	ARG121
R	ARG121
S	ARG121
B	ARG121
T	ARG121
C	ARG121
D	ARG121
E	ARG121
F	ARG121
G	ARG121
H	ARG121
I	ARG121

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)