3W1W

Protein-drug complex

Summary for 3W1W

Entry DOI	10.2210/pdb3w1w/pdb
Descriptor	Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, CHOLIC ACID, ... (6 entities in total)
Functional Keywords	heme synthesis inhibition, ferrochelatase, lyase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side: P22830
Total number of polymer chains	2
Total formula weight	89178.57
Authors	Ishii, R.,Gupta, V.,Yamaguchi, Y.,Handa, H.,Nureki, O. (deposition date: 2012-11-21, release date: 2013-10-09, Last modification date: 2023-11-08)
Primary citation	Gupta, V.,Liu, S.,Ando, H.,Ishii, R.,Tateno, S.,Kaneko, Y.,Yugami, M.,Sakamoto, S.,Yamaguchi, Y.,Nureki, O.,Handa, H. Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity Mol.Pharmacol., 84:824-833, 2013 Cited by PubMed: 24043703 DOI: 10.1124/mol.113.087940 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.006 Å)

Structure validation