3W0T

Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor

Summary for 3W0T

• Entry DOI: 10.2210/pdb3w0t/pdb
• Related: 3VW9 3W0U
• Descriptor: Lactoylglutathione lyase, ZINC ION, N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide, ... (5 entities in total)
• Functional Keywords: glyoxalase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 86746.10

Authors

Fukami, T.A.,Irie, M.,Matsuura, T. (deposition date: 2012-11-02, release date: 2013-11-06, Last modification date: 2023-11-08)

• Primary citation: Koyano, H.,Aoki, T.,Yamamoto, S.,Kobayashi, T.,Miura, T.,Ohara, K.,Fukami, T.A.,Irie, M.,Sakamoto, H.; N-Hydroxypyridone-based glyoxalase I inhibitors mimicking binding interactions of the substrate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.351 Å)