3W0T
Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Lactoylglutathione lyase | polymer | 187 | 21086.0 | 4 | UniProt (Q04760) Pfam (PF00903) In PDB | Homo sapiens (human) | Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B, C, D | N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide | non-polymer | 356.4 | 4 | Chemie (HPU) | |||
| 4 | B, D | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 3 | Chemie (EPE) | |||
| 5 | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 183 (UniProt: Q04760)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 84344.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2402.1 | |
| All* | Total formula weight | 86746.1 |
