3VW8
Crystal structure of human c-Met kinase domain with its inhibitor
Summary for 3VW8
Entry DOI | 10.2210/pdb3vw8/pdb |
Descriptor | Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 37593.85 |
Authors | Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Miki, H.,Nakamura, K.,Hori, A.,Imamura, S. (deposition date: 2012-08-08, release date: 2013-08-14, Last modification date: 2024-05-29) |
Primary citation | Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Nakamura, K.,Yamasaki, S.,Miki, H.,Hori, A.,Imamura, S. Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors. Bioorg.Med.Chem., 21:7686-7698, 2013 Cited by PubMed: 24216091DOI: 10.1016/j.bmc.2013.10.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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