3VW7

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

Summary for 3VW7

• Entry DOI: 10.2210/pdb3vw7/pdb
• Descriptor: Proteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: high resolution structure, protease-activated receptor 1, inactive conformation, antagonist vorapaxar, g protein-coupled receptor, signaling protein, membrane protein, thrombin receptor-antagonist complex, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P25116
• Total number of polymer chains: 1
• Total formula weight: 58098.87

Authors

Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K. (deposition date: 2012-08-07, release date: 2012-12-12, Last modification date: 2023-11-08)

• Primary citation: Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K.; High-resolution crystal structure of human protease-activated receptor 1; Nature, 492:387-392, 2012; PubMed: 23222541; DOI: 10.1038/nature11701

Experimental method

X-RAY DIFFRACTION (2.2 Å)