3VW6
Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor
Summary for 3VW6
Entry DOI | 10.2210/pdb3vw6/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase 5, 4-tert-butyl-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide (3 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q99683 |
Total number of polymer chains | 2 |
Total formula weight | 61314.07 |
Authors | Terao, Y.,Suzuki, H.,Yoshikawa, M.,Yashiro, H.,Takekawa, S.,Fujitani, Y.,Okada, K.,Inoue, Y.,Yamamoto, Y.,Nakagawa, H.,Yao, S.,Kawamoto, T.,Uchikawa, O. (deposition date: 2012-08-06, release date: 2012-10-31, Last modification date: 2024-03-20) |
Primary citation | Terao, Y.,Suzuki, H.,Yoshikawa, M.,Yashiro, H.,Takekawa, S.,Fujitani, Y.,Okada, K.,Inoue, Y.,Yamamoto, Y.,Nakagawa, H.,Yao, S.,Kawamoto, T.,Uchikawa, O. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg. Med. Chem. Lett., 22:7326-7329, 2012 Cited by PubMed: 23147077DOI: 10.1016/j.bmcl.2012.10.084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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