3VW6

Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase kinase kinase 5	polymer	269	30297.6	2	UniProt (Q99683) Pfam (PF00069) In PDB	Homo sapiens (human)	Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
2	A, B	4-tert-butyl-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	non-polymer		359.4	2	Chemie (IM6)
3		water	water		18.0	139	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60595.2
Non-Polymers*	Number of molecules	2
	Total formula weight	718.8
All*	Total formula weight	61314.1

*Water molecules are not included.