3VTB

Crystal structure of rat vitamin D receptor bound to a partial agonist 25-adamantyl-23-yne-19-norvitammin D ADTK1

Summary for 3VTB

Entry DOI	10.2210/pdb3vtb/pdb
Related	2ZLC 3VTC 3VTD
Descriptor	Vitamin D3 receptor, COACTIVATOR PEPTIDE DRIP, (1R,3R,7E,17beta)-17-{(2R,6S)-6-hydroxy-6-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]hex-4-yn-2-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
Functional Keywords	transcription, hormone receptor
Biological source	Rattus norvegicus (rats) More
Cellular location	Nucleus: P13053
Total number of polymer chains	2
Total formula weight	32684.71
Authors	Nakabayashi, M.,Kudo, T.,Tokiwa, H.,Makishima, M.,Yamada, S.,Ikura, T.,Ito, N. (deposition date: 2012-05-26, release date: 2013-06-12, Last modification date: 2024-03-20)
Primary citation	Kudo, T.,Ishizawa, M.,Maekawa, K.,Nakabayashi, M.,Watarai, Y.,Uchida, H.,Tokiwa, H.,Ikura, T.,Ito, N.,Makishima, M.,Yamada, S. Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor. J.Med.Chem., 2014 Cited by PubMed: 24773565 DOI: 10.1021/jm401989c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation