3VTD

Crystal structure of rat vitamin D receptor bound to a partial agonist 26-adamantyl-23-yne-19-norvitammin D ADTK4

Summary for 3VTD

• Entry DOI: 10.2210/pdb3vtd/pdb
• Related: 2ZLC 3VTB 3VTC
• Descriptor: Vitamin D3 receptor, COACTIVATOR PEPTIDE DRIP, (1R,3R,7E,17beta)-17-{(2R,6S)-6-hydroxy-7-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]hept-4-yn-2-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: transcription, hormone receptor
• Biological source: Rattus norvegicus (rats); More
• Cellular location: Nucleus: P13053
• Total number of polymer chains: 2
• Total formula weight: 32698.73

Authors

Nakabayashi, M.,Kudo, T.,Tokiwa, H.,Makishima, M.,Yamada, S.,Ikura, T.,Ito, N. (deposition date: 2012-05-26, release date: 2013-06-12, Last modification date: 2023-11-08)

• Primary citation: Kudo, T.,Ishizawa, M.,Maekawa, K.,Nakabayashi, M.,Watarai, Y.,Uchida, H.,Tokiwa, H.,Ikura, T.,Ito, N.,Makishima, M.,Yamada, S.; Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor.; J.Med.Chem., 2014; PubMed: 24773565; DOI: 10.1021/jm401989c

Experimental method

X-RAY DIFFRACTION (2.7 Å)