3VRR
Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide
3VRR の概要
エントリーDOI | 10.2210/pdb3vrr/pdb |
関連するPDBエントリー | 3VRN 3VRO 3VRP 3VRQ |
分子名称 | Signal transduction protein CBL-C, Epidermal growth factor receptor, CALCIUM ION, ... (4 entities in total) |
機能のキーワード | ptb domain, tkb (tyrosine kinase binding) domain, four-helix bundle (4h), calcium-binding ef hand, divergent sh2 domain, regulator of egfr mediated signal transduction, ubiquitously expressed, protein binding-transferase complex, protein binding/transferase |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Nucleus (Potential): Q9ULV8 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 38372.75 |
構造登録者 | Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. (登録日: 2012-04-13, 公開日: 2013-03-06) |
主引用文献 | Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Kim, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J.Biochem., 152:487-495, 2012 Cited by PubMed: 22888118DOI: 10.1093/jb/mvs085 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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