3VOL

X-ray Crystal Structure of PAS-HAMP Aer2 in the CN-bound Form

Summary for 3VOL

• Entry DOI: 10.2210/pdb3vol/pdb
• Descriptor: Aerotaxis transducer Aer2, PROTOPORPHYRIN IX CONTAINING FE, CYANIDE ION, ... (4 entities in total)
• Functional Keywords: heme, oxygen sensor protein, pas, hamp, cyanomet, cn-bound, signaling protein
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 26442.43

Authors

Sawai, H.,Sugimoto, H.,Shiro, Y.,Aono, S. (deposition date: 2012-01-27, release date: 2012-05-23, Last modification date: 2024-03-20)

Primary citation

Sawai, H.,Sugimoto, H.,Shiro, Y.,Ishikawa, H.,Mizutani, Y.,Aono, S.
Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa
Chem.Commun.(Camb.), 48:6523-6525, 2012

PubMed Abstract: The crystal structure of a truncated Aer2, a signal transducer protein from Pseudomonas aeruginosa, consisting of the heme-containing PAS and di-HAMP domains revealed that a distal tryptophan residue (Trp283) plays an important role in stabilizing the heme-bound O(2) and intra-molecular signal transduction upon O(2) binding.

PubMed: 22622145
DOI: 10.1039/c2cc32549g

Experimental method

X-RAY DIFFRACTION (2.399 Å)