3VOL

X-ray Crystal Structure of PAS-HAMP Aer2 in the CN-bound Form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM A 401

Chain	Residue
A	ALA189
A	ALA253
A	LEU255
A	TRP283
A	CYN402
A	HOH508
A	GLN216
A	ILE230
A	PHE233
A	HIS234
A	LYS235
A	HIS239
A	GLN240
A	HIS251

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CYN A 402

Chain	Residue
A	LEU255
A	TRP283
A	HEM401

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"PAS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00140","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Motif: {"description":"DxT. Important for signal propagation","evidences":[{"source":"PubMed","id":"34383467","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"22622145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23274111","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HI4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for gas binding and signaling","evidences":[{"source":"PubMed","id":"28167524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Plays a crucial role in stabilization of the heme-bound O(2)","evidences":[{"source":"PubMed","id":"22622145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28167524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---