3VHL

Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant)

Summary for 3VHL

Entry DOI	10.2210/pdb3vhl/pdb
Descriptor	Dedicator of cytokinesis protein 8, Cell division control protein 42 homolog, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	signal transduction, guanine nucleotide exchang factor, gtpase, signaling protein
Biological source	Mus musculus (mouse) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953
Total number of polymer chains	2
Total formula weight	55452.26
Authors	Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizak, T.,Terada, T.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. (deposition date: 2011-08-26, release date: 2012-06-20, Last modification date: 2023-11-08)
Primary citation	Harada, Y.,Tanaka, Y.,Terasawa, M.,Pieczyk, M.,Habiro, K.,Katakai, T.,Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizaki, T.,Shirouzu, M.,Duan, X.,Uruno, T.,Nishikimi, A.,Sanematsu, F.,Yokoyama, S.,Stein, J.V.,Kinashi, T.,Fukui, Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood, 119:4451-4461, 2012 Cited by PubMed: 22461490 DOI: 10.1182/blood-2012-01-407098 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.085 Å)

Structure validation