3VHL

Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant)

3VHL の概要

• エントリーDOI: 10.2210/pdb3vhl/pdb
• 分子名称: Dedicator of cytokinesis protein 8, Cell division control protein 42 homolog, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: signal transduction, guanine nucleotide exchang factor, gtpase, signaling protein
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55452.26

構造登録者

Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizak, T.,Terada, T.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. (登録日: 2011-08-26, 公開日: 2012-06-20, 最終更新日: 2023-11-08)

• 主引用文献: Harada, Y.,Tanaka, Y.,Terasawa, M.,Pieczyk, M.,Habiro, K.,Katakai, T.,Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizaki, T.,Shirouzu, M.,Duan, X.,Uruno, T.,Nishikimi, A.,Sanematsu, F.,Yokoyama, S.,Stein, J.V.,Kinashi, T.,Fukui, Y.; DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.; Blood, 119:4451-4461, 2012; PubMed: 22461490; DOI: 10.1182/blood-2012-01-407098

実験手法

X-RAY DIFFRACTION (2.085 Å)