3VEH

Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT

Summary for 3VEH

Entry DOI	10.2210/pdb3veh/pdb
Related	3RV6 3RV7 3RV8 3RV9 3ST6
Descriptor	Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, THIOCYANATE ION, ... (7 entities in total)
Functional Keywords	structural genomics, tb structural genomics consortium, tbsgc, salicylate synthase, lyase, isomerase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	197094.78
Authors	Bulloch, E.M.,Chi, G.,Manos-Turvey, A.,Johnston, J.M.,Baker, E.N.,Payne, R.J.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-01-08, release date: 2012-06-13, Last modification date: 2024-02-28)
Primary citation	Chi, G.,Manos-Turvey, A.,O'Connor, P.D.,Johnston, J.M.,Evans, G.L.,Baker, E.N.,Payne, R.J.,Lott, J.S.,Bulloch, E.M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51:4868-4879, 2012 Cited by PubMed: 22607697 DOI: 10.1021/bi3002067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation