3VA2

Crystal structure of human Interleukin-5 in complex with its alpha receptor

3VA2 の概要

• エントリーDOI: 10.2210/pdb3va2/pdb
• 分子名称: Interleukin-5, Interleukin-5 receptor subunit alpha (3 entities in total)
• 機能のキーワード: cytokine, eosinophilic, asthma, jak/stat, fibronectin iii-like (fn iii) domain, canonical cytokine receptor homology module (crm), b cell growth, ig secretion, eosinophils proliferation, cell surface, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P05113; Membrane; Single-pass type I membrane protein: Q01344
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 63142.30

構造登録者

Kusano, S.,Kukimoto-Niino, M.,Shirouzu, M.,Yokoyama, S. (登録日: 2011-12-28, 公開日: 2012-07-25)

• 主引用文献: Kusano, S.,Kukimoto-Niino, M.,Hino, N.,Ohsawa, N.,Ikutani, M.,Takaki, S.,Sakamoto, K.,Hara-Yokoyama, M.,Shirouzu, M.,Takatsu, K.,Yokoyama, S.; Structural basis of interleukin-5 dimer recognition by its alpha receptor; Protein Sci., 21:850-864, 2012; PubMed: 22528658; DOI: 10.1002/pro.2072

実験手法

X-RAY DIFFRACTION (2.703 Å)