3V9Y

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

3V9Y の概要

• エントリーDOI: 10.2210/pdb3v9y/pdb
• 関連するPDBエントリー: 3B1M 3LMP 3V9T 3V9V
• 分子名称: Peroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 4-{4-[({[(9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-yl]carbonyl}amino)methyl]naphthalen-2-yl}butanoic acid, ... (4 entities in total)
• 機能のキーワード: three-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34760.22

構造登録者

Matsui, Y.,Hanzawa, H. (登録日: 2011-12-28, 公開日: 2012-02-01, 最終更新日: 2023-11-08)

• 主引用文献: Furukawa, A.,Arita, T.,Fukuzaki, T.,Satoh, S.,Mori, M.,Honda, T.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Araki, K.,Ohsumi, J.; Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists; Bioorg.Med.Chem.Lett., 22:1348-1351, 2012; PubMed: 22225641; DOI: 10.1016/j.bmcl.2011.12.066

実験手法

X-RAY DIFFRACTION (2.1 Å)