3V9Y

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	283	32412.6	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (human)	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2	B	Peptide from Nuclear receptor coactivator 1	polymer	15	1776.1	1	UniProt (Q15788) In PDB	Homo sapiens	NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
3	A	4-{4-[({[(9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-yl]carbonyl}amino)methyl]naphthalen-2-yl}butanoic acid	non-polymer		571.6	1	Chemie (24L)
4		water	water		18.0	168	Chemie (HOH)

Sequence modifications

A: 206 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 195	-	expression tag
Arg 196	-	expression tag
Gly 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Gly 205	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34188.6
Non-Polymers*	Number of molecules	1
	Total formula weight	571.6
All*	Total formula weight	34760.2

*Water molecules are not included.