3V8S
Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)
Summary for 3V8S
| Entry DOI | 10.2210/pdb3v8s/pdb |
| Descriptor | Rho-associated protein kinase 1, 1-(1H-indazol-5-yl)-3-(2-phenylethyl)urea (3 entities in total) |
| Functional Keywords | kinase, dimerization, myosin, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: Q13464 |
| Total number of polymer chains | 4 |
| Total formula weight | 191063.94 |
| Authors | Martin, M.P.,Zhu, J.-Yi.,Schonbrunn, E. (deposition date: 2011-12-23, release date: 2012-02-08, Last modification date: 2023-09-13) |
| Primary citation | Li, R.,Martin, M.P.,Liu, Y.,Wang, B.,Patel, R.A.,Zhu, J.Y.,Sun, N.,Pireddu, R.,Lawrence, N.J.,Li, J.,Haura, E.B.,Sung, S.S.,Guida, W.C.,Schonbrunn, E.,Sebti, S.M. Fragment-based and structure-guided discovery and optimization of rho kinase inhibitors. J.Med.Chem., 55:2474-2478, 2012 Cited by PubMed: 22272748DOI: 10.1021/jm201289r PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.286 Å) |
Structure validation
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