3V7R

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor

Summary for 3V7R

Entry DOI	10.2210/pdb3v7r/pdb
Related	1HXD 2CGH 2EAY 2EWN 3V7C 3V7S 3V8J 3V8K 3V8L
Descriptor	Biotin ligase, (3aS,4S,6aR)-4-(5-{1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one (3 entities in total)
Functional Keywords	biotin, metabolism, biotin carboxyl carrier protein, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	38485.43
Authors	Yap, M.Y.,Pendini, N.R. (deposition date: 2011-12-21, release date: 2012-12-26, Last modification date: 2023-11-08)
Primary citation	Soares da Costa, T.P.,Tieu, W.,Yap, M.Y.,Pendini, N.R.,Polyak, S.W.,Sejer Pedersen, D.,Morona, R.,Turnidge, J.D.,Wallace, J.C.,Wilce, M.C.,Booker, G.W.,Abell, A.D. Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287:17823-17832, 2012 Cited by PubMed: 22437830 DOI: 10.1074/jbc.M112.356576 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation