3V4N
The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin
Summary for 3V4N
Entry DOI | 10.2210/pdb3v4n/pdb |
Related | 3V4X |
Descriptor | HMG-CoA synthase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total) |
Functional Keywords | hydroxymethylglutaryl-coa synthase, nitrosylation, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Enterococcus faecalis |
Total number of polymer chains | 4 |
Total formula weight | 170712.96 |
Authors | Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Geisbrecht, B.V.,Miziorko, H.M. (deposition date: 2011-12-15, release date: 2012-04-25, Last modification date: 2014-09-10) |
Primary citation | Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Barta, M.L.,Geisbrecht, B.V.,Miziorko, H.M. Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry, 51:4713-4722, 2012 Cited by PubMed: 22510038DOI: 10.1021/bi300037k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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