3V4I
Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP
Summary for 3V4I
Entry DOI | 10.2210/pdb3v4i/pdb |
Related | 1RTD 1VRT 2ZD1 3KLE 3KLF 3V6D 3V81 |
Descriptor | HIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (6 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, zidovudine, rt-dna complex, transferase-dna complex, drug resistance mutation, aids, dna recombination, dna-directed dna polymerase, rnase h, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-directed dna polymerase transferase, transferase-dna complex complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 8 |
Total formula weight | 259000.16 |
Authors | Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2011-12-15, release date: 2012-01-18, Last modification date: 2023-09-13) |
Primary citation | Das, K.,Martinez, S.E.,Bauman, J.D.,Arnold, E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19:253-259, 2012 Cited by PubMed: 22266819DOI: 10.1038/nsmb.2223 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7983 Å) |
Structure validation
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