3V4I
Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP
3V4I の概要
エントリーDOI | 10.2210/pdb3v4i/pdb |
関連するPDBエントリー | 1RTD 1VRT 2ZD1 3KLE 3KLF 3V6D 3V81 |
分子名称 | HIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (6 entities in total) |
機能のキーワード | hiv-1 reverse transcriptase, zidovudine, rt-dna complex, transferase-dna complex, drug resistance mutation, aids, dna recombination, dna-directed dna polymerase, rnase h, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-directed dna polymerase transferase, transferase-dna complex complex, transferase/dna |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 259000.16 |
構造登録者 | |
主引用文献 | Das, K.,Martinez, S.E.,Bauman, J.D.,Arnold, E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19:253-259, 2012 Cited by PubMed: 22266819DOI: 10.1038/nsmb.2223 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7983 Å) |
構造検証レポート
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