3V4I

Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP

3V4I の概要

• エントリーDOI: 10.2210/pdb3v4i/pdb
• 関連するPDBエントリー: 1RTD 1VRT 2ZD1 3KLE 3KLF 3V6D 3V81
• 分子名称: HIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (6 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, zidovudine, rt-dna complex, transferase-dna complex, drug resistance mutation, aids, dna recombination, dna-directed dna polymerase, rnase h, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-directed dna polymerase transferase, transferase-dna complex complex, transferase/dna
• 由来する生物種: Human immunodeficiency virus type 1 BH10 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 259000.16

構造登録者

Das, K.,Martinez, S.E.,Arnold, E. (登録日: 2011-12-15, 公開日: 2012-01-18, 最終更新日: 2023-09-13)

• 主引用文献: Das, K.,Martinez, S.E.,Bauman, J.D.,Arnold, E.; HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.; Nat.Struct.Mol.Biol., 19:253-259, 2012; PubMed: 22266819; DOI: 10.1038/nsmb.2223

実験手法

X-RAY DIFFRACTION (2.7983 Å)