3V19
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Summary for 3V19
Entry DOI | 10.2210/pdb3v19/pdb |
Related | 3V1G |
Descriptor | Insulin, ZINC ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | zinc-binding site, long-acting insulin analog, receptor binding, protein engineering, insulin fibrillation, hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 4 |
Total formula weight | 12033.28 |
Authors | Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A. (deposition date: 2011-12-09, release date: 2012-12-12, Last modification date: 2023-09-13) |
Primary citation | Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A. Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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