3UZA

Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine

Summary for 3UZA

Entry DOI	10.2210/pdb3uza/pdb
Related	3PWH 3REY 3RFM 3UZC
Descriptor	Adenosine receptor A2a, 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (2 entities in total)
Functional Keywords	7tm, gpcr, signaling protein, g-protein, membrane protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains	1
Total formula weight	36756.43
Authors	Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. (deposition date: 2011-12-07, release date: 2012-03-21, Last modification date: 2023-11-08)
Primary citation	Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design J.Med.Chem., 55:1898-1903, 2012 Cited by PubMed: 22220592 DOI: 10.1021/jm201376w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.273 Å)

Structure validation