3UZA

Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine

3UZA の概要

• エントリーDOI: 10.2210/pdb3uza/pdb
• 関連するPDBエントリー: 3PWH 3REY 3RFM 3UZC
• 分子名称: Adenosine receptor A2a, 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (2 entities in total)
• 機能のキーワード: 7tm, gpcr, signaling protein, g-protein, membrane protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P29274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36756.43

構造登録者

Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. (登録日: 2011-12-07, 公開日: 2012-03-21, 最終更新日: 2023-11-08)

• 主引用文献: Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H.; Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design; J.Med.Chem., 55:1898-1903, 2012; PubMed: 22220592; DOI: 10.1021/jm201376w

実験手法

X-RAY DIFFRACTION (3.273 Å)