3UXH

Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors of Quinone Reductase 2

Summary for 3UXH

Entry DOI	10.2210/pdb3uxh/pdb
Related	3UXE
Descriptor	Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	quinone reductase, cytosol, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P16083
Total number of polymer chains	2
Total formula weight	53983.98
Authors	Cushman, M.,Mesecar, A.D.,Fanwick, P.E.,Narasimha, R.,Jensen, K.C. (deposition date: 2011-12-05, release date: 2012-01-18, Last modification date: 2022-12-21)
Primary citation	Reddy, P.V.,Jensen, K.C.,Mesecar, A.D.,Fanwick, P.E.,Cushman, M. Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2. J.Med.Chem., 55:367-377, 2012 Cited by PubMed: 22206487 DOI: 10.1021/jm201251c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation