3UXE

Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors for Quinone Reductase 2

Summary for 3UXE

• Entry DOI: 10.2210/pdb3uxe/pdb
• Related: 3UXH
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: flavoprotein, quinone reductase, cytosol, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 54100.10

Authors

Reddy, N.P.,Jensen, K.C.,Mesecar, A.D.,Fanwick, P.E.,Cushman, M. (deposition date: 2011-12-05, release date: 2012-01-18, Last modification date: 2022-12-21)

• Primary citation: Reddy, P.V.,Jensen, K.C.,Mesecar, A.D.,Fanwick, P.E.,Cushman, M.; Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2.; J.Med.Chem., 55:367-377, 2012; PubMed: 22206487; DOI: 10.1021/jm201251c

Experimental method

X-RAY DIFFRACTION (1.5 Å)