3UX9

Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

3UX9 の概要

• エントリーDOI: 10.2210/pdb3ux9/pdb
• 分子名称: Interferon alpha-1/13, ScFv antibody (3 entities in total)
• 機能のキーワード: five helices, long loop connecting helix, hydrophobic interactions, cytokine-immune system complex, cytokine/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01562
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93994.74

構造登録者

Ouyang, S.,Zhao, L.X.,Liang, W.,Shaw, N.,Liu, Z.-J.,Liang, M.-F. (登録日: 2011-12-04, 公開日: 2012-02-29)

• 主引用文献: Ouyang, S.,Gong, B.,Li, J.-Z.,Zhao, L.-X.,Wu, W.,Zhang, F.-S.,Sun, L.,Wang, S.-J.,Pan, M.,Li, C.,Liang, W.,Shaw, N.,Zheng, J.,Zhao, G.-P.,Wang, Y.,Liu, Z.-J.,Liang, M.-F.; Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus; J.Mol.Med., 2012; PubMed: 22307521; DOI: 10.1007/s00109-012-0866-3

実験手法

X-RAY DIFFRACTION (2.8 Å)