3UWP

Crystal structure of Dot1l in complex with 5-iodotubercidin

Summary for 3UWP

Entry DOI	10.2210/pdb3uwp/pdb
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, IODIDE ION, ... (6 entities in total)
Functional Keywords	histone, methyltransferase, epigenetics, tubercidin, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q8TEK3
Total number of polymer chains	1
Total formula weight	50792.96
Authors	Yu, W.,Tempel, W.,Smil, D.,Schapira, M.,Li, Y.,Vedadi, M.,Nguyen, K.T.,Wernimont, A.K.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2011-12-02, release date: 2012-03-14, Last modification date: 2024-02-28)
Primary citation	Yu, W.,Chory, E.J.,Wernimont, A.K.,Tempel, W.,Scopton, A.,Federation, A.,Marineau, J.J.,Qi, J.,Barsyte-Lovejoy, D.,Yi, J.,Marcellus, R.,Iacob, R.E.,Engen, J.R.,Griffin, C.,Aman, A.,Wienholds, E.,Li, F.,Pineda, J.,Estiu, G.,Shatseva, T.,Hajian, T.,Al-Awar, R.,Dick, J.E.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Bradner, J.E.,Schapira, M. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun, 3:1288-1288, 2012 Cited by PubMed: 23250418 DOI: 10.1038/ncomms2304 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation