3UVN

Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A

Summary for 3UVN

• Entry DOI: 10.2210/pdb3uvn/pdb
• Related: 3UVK 3UVL 3UVM 3UVO
• Descriptor: WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1A (3 entities in total)
• Functional Keywords: trithorax, chromatin biology, beta-propeller, scaffolding, histone h3, nucleus, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P61964; Nucleus speckle: O15047
• Total number of polymer chains: 4
• Total formula weight: 71989.46

Authors

Zhang, P.,Lee, H.,Brunzelle, J.S.,Couture, J.-F. (deposition date: 2011-11-30, release date: 2011-12-14, Last modification date: 2023-09-13)

• Primary citation: Zhang, P.,Lee, H.,Brunzelle, J.S.,Couture, J.F.; The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.; Nucleic Acids Res., 40:4237-4246, 2012; PubMed: 22266653; DOI: 10.1093/nar/gkr1235

Experimental method

X-RAY DIFFRACTION (1.792 Å)