3UP3

Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid

Summary for 3UP3

• Entry DOI: 10.2210/pdb3up3/pdb
• Related: 3UP0
• Descriptor: aceDAF-12, Nuclear receptor coactivator 2, (8alpha,10alpha,25S)-3-hydroxycholesta-3,5-dien-26-oic acid, ... (5 entities in total)
• Functional Keywords: ligand binding domain, nematode, steroid binding protein-transcription complex, steroid binding protein/transcription
• Biological source: Ancylostoma ceylanicum; More
• Cellular location: Nucleus: Q15596
• Total number of polymer chains: 2
• Total formula weight: 30238.62

Authors

Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E. (deposition date: 2011-11-17, release date: 2011-12-14, Last modification date: 2024-02-28)

• Primary citation: Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E.; Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.; J.Biol.Chem., 287:4894-4903, 2012; PubMed: 22170062; DOI: 10.1074/jbc.M111.315242

Experimental method

X-RAY DIFFRACTION (1.25 Å)