3UP3

Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0030154	biological_process	cell differentiation
A	0030522	biological_process	intracellular receptor signaling pathway
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE XCA A 100

Chain	Residue
A	HOH19
A	ILE657
A	SER661
A	LEU664
A	THR495
A	LEU529
A	THR530
A	ARG532
A	GLY533
A	THR546
A	PRO547
A	GLN571

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 200

Chain	Residue
A	HOH12
A	PRO468
A	MET469
A	THR548

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 300

Chain	Residue
A	ALA461
A	PHE462
A	LYS463
A	GLY464
A	MET465
A	ARG498
A	MET502

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 400

Chain	Residue
A	SER484
A	PRO485
A	ALA486
A	GLU612
A	ARG615
A	THR668
A	ASN670
A	GLU673

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 686

Chain	Residue
A	HOH15
A	HOH61
A	MET469
A	GLU470
A	GLN474
A	ASP606

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 687

Chain	Residue
A	SER513
A	SER607
A	ILE608
A	THR609
A	ASP610
A	ASP613

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site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 700

Chain	Residue
A	HOH33
A	PHE478
A	LEU479
A	LYS480
A	ASN481
A	LYS483
A	SER552
A	SER553
A	GLU554
A	ARG574

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