3UFN

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir

3UFN の概要

• エントリーDOI: 10.2210/pdb3ufn/pdb
• 関連するPDBエントリー: 3UCB 3UF3 3UHL
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: HIV-1 protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22945.67

構造登録者

Agniswamy, J.,Chen-Hsiang, S.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. (登録日: 2011-11-01, 公開日: 2012-03-28, 最終更新日: 2024-02-28)

• 主引用文献: Agniswamy, J.,Shen, C.H.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T.; HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.; Biochemistry, 51:2819-2828, 2012; PubMed: 22404139; DOI: 10.1021/bi2018317

実験手法

X-RAY DIFFRACTION (1.45 Å)