3UF2
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine
Summary for 3UF2
Entry DOI | 10.2210/pdb3uf2/pdb |
Related | 1HMC 3UEZ 3UF5 |
Descriptor | Macrophage colony-stimulating factor 1 (2 entities in total) |
Functional Keywords | hematopoietic cytokine, rtkiii, four-helix bundle, cytokine |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space: P09603 |
Total number of polymer chains | 10 |
Total formula weight | 178682.19 |
Authors | Elegheert, J.,Savvides, S.N. (deposition date: 2011-10-31, release date: 2012-08-22, Last modification date: 2013-07-17) |
Primary citation | Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N. Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1 Nat.Struct.Mol.Biol., 19:938-947, 2012 Cited by PubMed: 22902366DOI: 10.1038/nsmb.2367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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