3UCR

Crystal structure of the immunoreceptor TIGIT IgV domain

3UCR の概要

• エントリーDOI: 10.2210/pdb3ucr/pdb
• 分子名称: T cell immunoreceptor with Ig and ITIM domains, CHLORIDE ION (3 entities in total)
• 機能のキーワード: pvr/tigit/nectins/ig superfamily/signal transduction, igsf, immuno receptor, pvr, nectin-2, nectin-3, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: Q495A1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48192.78

構造登録者

Yin, J.P.,Stengel, K.F.,Rouge, L.,Bazan, J.F.,Wiesmann, C. (登録日: 2011-10-27, 公開日: 2012-03-14, 最終更新日: 2012-04-25)

• 主引用文献: Stengel, K.F.,Harden-Bowles, K.,Yu, X.,Rouge, L.,Yin, J.,Comps-Agrar, L.,Wiesmann, C.,Bazan, J.F.,Eaton, D.L.,Grogan, J.L.; Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.; Proc.Natl.Acad.Sci.USA, 109:5399-5404, 2012; PubMed: 22421438; DOI: 10.1073/pnas.1120606109

実験手法

X-RAY DIFFRACTION (2.627 Å)