3UBT

Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA

3UBT の概要

• エントリーDOI: 10.2210/pdb3ubt/pdb
• 分子名称: Modification methylase HaeIII, 5'-D(*TP*GP*GP*CP*CP*A)-3', CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: protein-dna complex, dna cytosine-5 methyltransferase, dna binding, s-adenosyl methionine binding, cytosine-5 dna methylation, transferase-dna complex, transferase/dna
• 由来する生物種: Haemophilus aegyptius (Koch-Weeks bacillus)
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 127238.71

構造登録者

Verdine, G.L.,Didovyk, A. (登録日: 2011-10-24, 公開日: 2012-10-03, 最終更新日: 2024-02-28)

主引用文献

Didovyk, A.,Verdine, G.L.
Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase.
J.Biol.Chem., 287:40099-40105, 2012

PubMed Abstract: How DNA 5-cytosine methyltransferases (DCMTases) select their substrate nucleobase for extrusion from DNA duplex is poorly understood.

PubMed: 23012373
DOI: 10.1074/jbc.M112.413054

実験手法

X-RAY DIFFRACTION (2.502 Å)