3U8B

Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

3U8B の概要

• エントリーDOI: 10.2210/pdb3u8b/pdb
• 関連するPDBエントリー: 3U8D 3U8H 3U8I
• 分子名称: Phospholipase A2, membrane associated, CHLORIDE ION, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: secreted phospholipase a2, phospholipase a2 activity, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Peripheral membrane protein: P14555
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14096.07

構造登録者

Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.-W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F. (登録日: 2011-10-16, 公開日: 2012-10-17, 最終更新日: 2013-06-12)

• 主引用文献: Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F.; Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes.; J.Biol.Chem., 288:15269-15279, 2013; PubMed: 23482564; DOI: 10.1074/jbc.M112.397893

実験手法

X-RAY DIFFRACTION (2.299 Å)