3U8B

Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006954	biological_process	inflammatory response
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030141	cellular_component	secretory granule
A	0031640	biological_process	killing of cells of another organism
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0036335	biological_process	intestinal stem cell homeostasis
A	0042742	biological_process	defense response to bacterium
A	0046337	biological_process	phosphatidylethanolamine metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046473	biological_process	phosphatidic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0047499	molecular_function	calcium-independent phospholipase A2 activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050482	biological_process	arachidonate secretion
A	0050729	biological_process	positive regulation of inflammatory response
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	1902563	biological_process	regulation of neutrophil activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 125

Chain	Residue
A	GLY32
A	ASN114
A	LYS115

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 126

Chain	Residue
A	PHE23
A	GLY25
A	TYR112
A	ASN114
A	HOH134
A	HOH152

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 127

Chain	Residue
A	HIS27
A	GLY29
A	GLY31
A	ASP48

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 128

Chain	Residue
A	ASN4
A	ARG7
A	ARG118

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Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCVtHDcC

Chain	Residue	Details
A	CYS43-CYS50

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAAaTC

Chain	Residue	Details
A	LEU87-CYS97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS47
A	ASP91

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:1948070, ECO:0000269|PubMed:7664108, ECO:0000312|PDB:1DB4, ECO:0000312|PDB:1DB5, ECO:0000312|PDB:1DCY, ECO:0000312|PDB:1POE

Chain	Residue	Details
A	HIS27
A	GLY29
A	GLY31
A	ASP48

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important for integrin binding => ECO:0000269|PubMed:18635536

Chain	Residue	Details
A	ARG74
A	ARG100

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