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3U8B

Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004623molecular_functionphospholipase A2 activity
A0005509molecular_functioncalcium ion binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006954biological_processinflammatory response
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0030141cellular_componentsecretory granule
A0031640biological_processkilling of cells of another organism
A0034374biological_processlow-density lipoprotein particle remodeling
A0036335biological_processintestinal stem cell homeostasis
A0038166biological_processangiotensin-activated signaling pathway
A0042130biological_processnegative regulation of T cell proliferation
A0042742biological_processdefense response to bacterium
A0046337biological_processphosphatidylethanolamine metabolic process
A0046470biological_processphosphatidylcholine metabolic process
A0046471biological_processphosphatidylglycerol metabolic process
A0046473biological_processphosphatidic acid metabolic process
A0046872molecular_functionmetal ion binding
A0047498molecular_functioncalcium-dependent phospholipase A2 activity
A0048471cellular_componentperinuclear region of cytoplasm
A0050482biological_processarachidonate secretion
A0050729biological_processpositive regulation of inflammatory response
A0050830biological_processdefense response to Gram-positive bacterium
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A1902563biological_processregulation of neutrophil activation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 125
ChainResidue
AGLY32
AASN114
ALYS115

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 126
ChainResidue
APHE23
AGLY25
ATYR112
AASN114
AHOH134
AHOH152

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 127
ChainResidue
AHIS27
AGLY29
AGLY31
AASP48

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 128
ChainResidue
AASN4
AARG7
AARG118

Functional Information from PROSITE/UniProt
site_idPS00118
Number of Residues8
DetailsPA2_HIS Phospholipase A2 histidine active site. CCVtHDcC
ChainResidueDetails
ACYS43-CYS50

site_idPS00119
Number of Residues11
DetailsPA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAAaTC
ChainResidueDetails
ALEU87-CYS97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1948070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7664108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DB5","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DCY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1POE","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsSite: {"description":"Important for integrin binding","evidences":[{"source":"PubMed","id":"18635536","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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