3U88

Crystal structure of human menin in complex with MLL1 and LEDGF

Summary for 3U88

• Entry DOI: 10.2210/pdb3u88/pdb
• Related: 3U84 3U85 3U86
• Descriptor: Menin, Histone-lysine N-methyltransferase 2A, Lens epithelium-derived growth factor, ... (8 entities in total)
• Functional Keywords: menin, men1, mll, jund, ledgf, tpr, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O00255 O75475; Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 6
• Total formula weight: 161943.68

Authors

Huang, J.,Wan, B.,Lei, M. (deposition date: 2011-10-16, release date: 2012-02-15, Last modification date: 2023-11-15)

• Primary citation: Huang, J.,Gurung, B.,Wan, B.,Matkar, S.,Veniaminova, N.A.,Wan, K.,Merchant, J.L.,Hua, X.,Lei, M.; The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.; Nature, 482:542-546, 2012; PubMed: 22327296; DOI: 10.1038/nature10806

Experimental method

X-RAY DIFFRACTION (3 Å)