3U5J
Crystal Structure of the first bromodomain of human BRD4 in complex with Alprazolam
Summary for 3U5J
Entry DOI | 10.2210/pdb3u5j/pdb |
Related | 3U5K 3U5L |
Descriptor | Bromodomain-containing protein 4, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, structural genomics consortium, sgc, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15656.42 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-10-11, release date: 2011-11-23, Last modification date: 2023-09-13) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Keller, M.,Wrobel, M.,Morgenstern, O.,Bracher, F.,Knapp, S. Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20:1878-1886, 2012 Cited by PubMed: 22137933DOI: 10.1016/j.bmc.2011.10.080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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