3U5J
Crystal Structure of the first bromodomain of human BRD4 in complex with Alprazolam
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
2 | A | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | non-polymer | 308.8 | 1 | Chemie (08H) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 43 | Thr 43 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15099.4 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 557.0 | |
All* | Total formula weight | 15656.4 |