3U23

Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3

Summary for 3U23

• Entry DOI: 10.2210/pdb3u23/pdb
• Related: 2FEI 2KRN 4WCI
• Descriptor: CD2-associated protein, Ras and Rab interactor 3, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, beta-barrel, adaptor protein, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton : Q9Y5K6; Cytoplasm : Q8TB24
• Total number of polymer chains: 2
• Total formula weight: 9309.63

Authors

Simister, P.C.,Rouka, E.,Janning, M.,Muniz, J.R.C.,Kirsch, K.H.,Knapp, S.,von Delft, F.,Filippakopoulos, P.,Arrowsmith, C.H.,Krojer, T.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Feller, S.M.,Structural Genomics Consortium (SGC) (deposition date: 2011-09-30, release date: 2011-12-28, Last modification date: 2023-09-13)

• Primary citation: Rouka, E.,Simister, P.C.,Janning, M.,Kumbrink, J.,Konstantinou, T.,Muniz, J.R.,Joshi, D.,O'Reilly, N.,Volkmer, R.,Ritter, B.,Knapp, S.,von Delft, F.,Kirsch, K.H.,Feller, S.M.; Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).; J.Biol.Chem., 290:25275-25292, 2015; PubMed: 26296892; DOI: 10.1074/jbc.M115.637207

Experimental method

X-RAY DIFFRACTION (1.11 Å)