3U0X

Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382

3U0X の概要

• エントリーDOI: 10.2210/pdb3u0x/pdb
• 関連するPDBエントリー: 1LZ7 1LZJ 2RIT 2RIX 2RJ8
• 分子名称: Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: rossmann fold, open conformation, glycosyltransferase, transferase gtb, abo, blood group antigen, glycoprotein, metal-binding, manganese, udp-gal, h-antigen acceptor, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71304.93

構造登録者

Palcic, M.M.,Jorgensen, R. (登録日: 2011-09-29, 公開日: 2012-10-24, 最終更新日: 2023-09-13)

• 主引用文献: Jorgensen, R.,Grimm, L.L.,Sindhuwinata, N.,Peters, T.,Palcic, M.M.; A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding; To be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)