3TZA

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution

3TZA の概要

• エントリーDOI: 10.2210/pdb3tza/pdb
• 関連するPDBエントリー: 1FTL 1N0T
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, glua2-s1s2j, antagonist, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59461.00

構造登録者

Frydenvang, K.,Kastrup, J.S. (登録日: 2011-09-27, 公開日: 2011-10-26, 最終更新日: 2023-11-01)

• 主引用文献: Szymanska, E.,Frydenvang, K.,Contreras-Sanz, A.,Pickering, D.S.,Frola, E.,Serafimoska, Z.,Nielsen, B.,Kastrup, J.S.,Johansen, T.N.; A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure; J.Med.Chem., 54:7289-7298, 2011; PubMed: 21923187; DOI: 10.1021/jm200862h

実験手法

X-RAY DIFFRACTION (1.9 Å)